HOME ＞ 論文等

2024

論文

（*Corresponding author）

  1. Ikeda, C., Mori, A., Hosokawa, K., Iwaoka, Y., Uemura, T., and Ito, H.* (2024) In vivo behavior of hydrolyzable tannins after oral administration of the Trapa bispinosa extract to rats, J. Agric. Food Chem., 72, 9190-9198.
    https://doi.org/10.1021/acs.jafc.4c00574 
  2. Koga, T., Kawahara, N., Aburada, M., Ono, A., Mae, S., Yoshida, A., Iwaoka, Y., Ito, H., and Tai, A. (2024) Antiallergic activity of 3-O-dodecyl-L-ascorbic acid, Molecules, 29(1), 69.
    https://doi.org/10.3390/molecules29010069

2023

論文

（*Corresponding author）

  1. Ho, K-V., Hsieh, H-Y., Roy, A., Foote, S., McDonald, P., Coggeshall, M. V., Ito, H., Lei, Z., Sumner, L. W., Stewart, G. C., and Lin, C-Ho. (2023) Quantification and characterization of biological activities of glansreginin A in black walnuts (Juglans nigra), Sci. Rep., 13, 18860.
    https://doi.org/10.1038/s41598-023-46134-8
  2. Uchikura, T., Miura, Y., Yoshimura, M., Ito, H., and Amakura, Y. (2023) Identification of antioxidative hydrolyzable tannins in water chestnut, Molecules, 28(18), 6563.
    https://doi.org/10.3390/molecules28186563
  3. Oda-Yamamizo, C, Mitsuda, M., Milkowski, C., Ito, H., Ezura, K., and Tahara, K. (2023) Heterologous gene expression system for the production of hydrolyzable tannin intermediates in herbaceous model plants, J. Plant Res., 136, 891-905
  4. Furuta, A., Ikegami, M., Yaguchi, T., Ito, H., Tanaka, K., Nishinari, K., Nitta, Y. (2023) Transparent thermoreversible gels of β-(1 → 6)-branched β-(1 → 3)-glucan derived from the cauliflower mushroom Sparassis crispa, Food Hydrocolloids, 142 , 108766.
    https://doi.org/10.1016/j.foodhyd.2023.108766

著書

  1. 伊東秀之 (2023) 分類と化学構造，ポリフェノールの科学（基礎化学から健康機能まで），監修：寺尾純二，下位香代子，
    朝倉書店，4-13.

寄稿，Proceedings，報告書等書

  1. Chiaki Ikeda, Ayaka Mori, Kanano Hosokawa, Yuji Iwaoka, and Hideyuki Ito, Bioavailability of hydrolyzable tannins after oral administration of Trapa bispinosa extract in rats, Polyphenols Communications 2023, e-vol.2, 138. e-ISSN 2957-4056
  2. Mayu Kuwamura, Mao Kanada, Natsuki Ganeko, Yuji Iwaoka, and Hideyuki Ito, Changes in composition of Ellagitannins during ripening of pomegranate fruits, Polyphenols Communications 2023, e-vol.2, 231. e-ISSN 2957-4056
  3. Yuji Iwaoka, Chisa Hayakawa, Shoichi Suzuki, Nana Kato, Satoko Kawabe, Natsuki Ganeko, Tomohiro Uemura, and Hideyuki Ito, Polyphenols with antiglycation properties in Trapa pericarp extract, Polyphenols Communications 2023, e-vol.2, 62. e-ISSN 2957-4056
  4. Ko Tahara, Mitsuru Nishiguchi, Hideyuki Ito, Milkowski Carsten, Genetic transformation of Eucalyptus camaldulensis to suppress hydrolyzable tannin biosynthesis, Polyphenols Communications 2023, e-vol.2, 225. e-ISSN 2957-4056

2022

論文

（*Corresponding author）

  1. Koga, T., Ito, H., Iwaoka, Y., Noshita, T., Tai, A. (2022) Neurite outgrowth-promoting compounds from the petals of Paeonia lactiflora in PC12 cells, Molecules, 27 (22), 7670.
    https://doi.org/10.3390/molecules27227670
  2. Koga,T., Shiki, N., Ito, H., Iwaoka, Y., Tai, A.(2022) Degranulation inhibitors from petals of Coreopsis
    grandiflora    , Rec. Nat. Prod., 16, 645-650.
    http://doi.org/10.25135/rnp.319.2202.2351
  3. Iwaoka, Y., Misaki, F., Ito, H., Koga, T., Kawahara, N., Tai, A. (2022) Synthesis of ascorbic acid derivatives with different types of C8 straight acyl chain and their neurite outgrowth-enhancing activities, J. Nutr. Sci. Vitaminol., 68 (3), 236-239.
    https://doi.org/10.3177/jnsv.68.236
  4. Tsukayama, I., Kawakami, Y., Tamenobu, A., Toda, K., Maruoka, S., Nagasaki, Y., Mori, Y., Sawazumi, R., Okamoto, K., Kanzaki, K., Ito, H., Yakahashi, Y., Miki Y., Yamamoto, K., Murakami, M., Suzuki-Yamamoto, T. (2022) Malabaricone C derived from nutmeg inhibits arachidonate 5-lipoxygenase activity and ameliorates psoriasis-like skin inflammation in mice, Free Radic. Biol. Med., 193, 1-8.
    https://doi.org/10.1016/j.freeradbiomed.2022.09.028

著書

  1. 伊東秀之 (2022) ポリフェノールの生体内代謝産物の機能性，ポリフェノールの機能と多角的応用，Functions of Polyphenols and Their Multifaceted Applications，監修：田中隆，シーエムシー出版，79-85.
  2. 岩岡裕二, 福嶋美咲, 伊東秀之, 田井章博 (2022) 2-O-α-D-Glucopyranosyl-6-O-(2-propylpentanoyl)-L-ascorbic acidの高効率的かつ低コストな合成プロセス, ビタミン, 96 (5・6), 230-233.
  3. 三浦香織, 松野弘明, 岩岡裕二, 伊東秀之, 田井章博 (2021) 6-Deoxy-2-O-methyl-6-(N-hexadecanoyl)amino-L-ascorbic acidの抗アレルギー作用, ビタミン, 95 (11), 483-486.

紀要

  1. 佐竹 恭介，喜村 仁詞，横田 英之，平田 英俊，伊東 秀之（2022）志願者数 解析による岡山県立大学における入試制度の考察，岡山県立大学教育研究紀要，7(1)， 57-63.
    doi/10.15009/00002457
  2. 我如古 菜月，古川 健斗，渡澤 恭介，新田 陽子，加賀田 江里，田淵 真愉美，伊東 秀之 （2022）
    低価格米粉の基礎分析および加工適性に関する研究，福山大学生命工学部年報，（21），33-40. 

2021

論文

（*Corresponding author）

  1. Iwaoka, Y., Suzuki, S., Kato, N., Hayakawa, C., Kawabe, S., Ganeko, N., Uemura, T., Ito, H.* (2021) Characterization and identification of bioactive polyphenols in the Trapa bispinosa Roxb. pericarp extract, Molecules, 26 (19), 5802.
    https://doi.org/10.3390/molecules26195802
  2. Iwaoka, Y., Fukushima, M., Ito, H., Tai, A. (2021) Highly efficient and low-cost process for synthesis of 2-O-α-D-glucopyranosyl-6-O-(2-propylpentanoyl)-L-ascorbic acid, Process Biochemistry, 111 (Part 1) , 71-77.
    https://doi.org/10.1016/j.procbio.2021.09.004
  3. Miura, K., Matsuno, K., Iwaoka, Y., Ito, H., Tai, A. (2021) Antiallergic Activity of 6-Deoxy-2-O-methyl-6-(N-hexadecanoyl)amino-L-ascorbic Acid, Molecules, 26 (15) , 4684. https://doi.org/10.3390/molecules26154684
  4. Yamada, N., Yamasaki, T., Yamawaki, K., Nakagiri, M., Ito, H., Nakamura, Y., Nakanishi, T. (2021) Functional Evaluation of the Ethanol Extracts from Rosmarinus officinalis L. (Rosemary), J. Hard Tissue Biol. , 30 (3) , 291-296. https://doi.org/10.2485/jhtb.30.291

教科書

  1. 伊東秀之（2021）ポリフェノール　構造・化学，ビタミン・バイオファクター総合事典, 日本ビタミン学会編集，朝倉書店

2020

論文

（*Corresponding author）

  1. Takeshima, D., Mori, A., Ito, H., Komori, H., Ueno, H., Nitta, Y. (2020) A single amino acid substitution converts a histidine decarboxylase to an imidazole acetaldehyde synthase, Arch. Biochem. Biophys., 693, 108551. https://doi.org/10.1016/j.abb.2020.108551
  2. Iwaoka, Y., Ikeda, N., Ohno, A., Ito, H., and Tai, A. (2020) Antioxidant activity and neurite outgrowth-enhancing activity of scorbamic acid and a red pigment derived from ascorbic acid, Nat. Prod. Res., 34, 838-842. https://doi.org/10.1080/14786419.2018.1499641
  3. Toda, K., Tsukayama, I,. Nagasaki, Y., Konoike Y., Tamenobu, A., Ganeko, N., Ito, H., Takahashi, Y., Miki, Y., Yamamoto, K., Murakami, M., Kawakami, Y., Suzuki-Yamamoto, T. (2020) Red-kerneled rice proanthocyanidin inhibits arachidonate 5-lipoxygenase and decreases psoriasis-like skin inflammation, Arch. Biochem. Biophys., 689, 108307. https://doi.org/10.1016/j.abb.2020.108307
  4. Toda, K., Ueyama, m., Tanaka, S., Tsukayama, I., Mega, T., Konoike, Y., Tamenobu, A., Bastian, F., Akai, I., Ito, H., Kawakami , Y., Takahashi, Y., Suzuki-Yamamoto, T. (2020) Ellagitannins from Punica granatum leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis, Biosci. Biotech. Biochem., 84 (4), 757-763. https://doi.org/10.1080/09168451.2019.1706442
  5. Yoshimura, M., Amakura,Y., Hyuga, S., Hyuga, M., Nakamori, S., Maruyama, T., Oshima, N., Uchiyama, N.,Yang, J., Oka, H., Ito, H., Kobayashi, Y., Odaguchi, H., Hakamatsuka, T., Hanawa, T., Goda, Y. (2020) Quality evaluation and characterization of fractions with biological activity from Ephedra herb extract and ephedrine alkaloids-free Ephedra herb extract, Chem. Pharm. Bull., 68 (2), 140-149.https://doi.org/10.1248/cpb.c19-00761
    ★Highlightedpaper selected by Editor-in-Chief に選ばれました
  6. Haramiishi, R., Okuyama, S., Yoshimura, M.,Nakajima, M., Furukawa, Y., Ito, H., Amakura, Y. (2020) Identification of the characteristic components in walnut and anti-inflammatory effect of glansreginin A as an indicator for quality evaluation, Biosci. Biotech. Biochem., 84(1), 187-197. https://doi.org/10.1080/09168451.2019.1670046

総説，著書

（*Corresponding author）

  1. Hideyuki Ito* (2020) Foreword, Current Topics – New Era of Polyphenol Research，Chem. Pharm. Bull.，68 (12), 1121-1122. https://doi.org/10.1248/cpb.c20-ctf6812

2019

論文

（*Corresponding author）

  1. Nitta, Y., Ito, H., Komori, H., Ueno, H., Takeshima, D., Ito, M., Sakaue, M., Kikuzaki, H. (2019) The ellagitannin trimer rugosin G inhibits recombinant human histidine decarboxylase, Biosci. Biotech. Biochem., 83(7), 1315-1318. https://doi.org/10.1080/09168451.2019.1606695
  2. Morishita, Y., Ikeda, K., Matsuno, H., Ito, H., and Tai, A. (2019) Identification of degranulation inhibitors from rooibos (Aspalathus linearis) tea in rat basophilic leukaemia cells, Nat. Prod. Res., 33(10), 1472-1476. https://doi.org/10.1080/14786419.2017.1416377
  3. Ganeko, N., Kato, N., Watanabe, S., Bastian, F., Miyake, M., and Ito, H.* (2019) Proanthocyanidin and anthocyanins from the hulls and beards of red-kerneled rice and their antiglycation properties, Biosci. Biotech. Biochem., 83(4), 605-608. https://doi.org/10.1080/09168451.2018.1553609
  4. Nagano, T., Ito, H. (2019) Diets containing pomegranate polyphenol and soy isoflavone attenuate contact hypersensitivity in mice, Biosci. Biotech. Biochem., 83(3), 525-530. https://doi.org/10.1080/09168451.2018.1543013
  5. Kawakami, Y., Otsuki, A., Mori, Y., Kanzaki, K., Suzuki-Yamamoto, T., Fang, D.H., Ito, H., Takahashi, Y. (2019) Involvement of the Hydroperoxy Group in the Irreversible Inhibition of Leukocyte-Type 12-Lipoxygenase by Monoterpene Glycosides Contained in the Qing Shan Lu Shui Tea, Molecules, 24 (2), 304. https://doi.org/10.3390/molecules24020304

総説，著書

（*Corresponding author）

  1. 伊東秀之* (2019) エラジタンニンの腸内細菌に与える影響，アグリバイオ，3 (13), 54-58.
  2. Special Issue Dedicated to Late Professor Takuo Okuda, Tannins and Related Polyphenols Revisited: Chemistry, Biochemistry and Biological Activities Edited by Ito, H., Hatano, T., Yoshida, T., MDPI books, Switzerland, 1-316 (2019) DOI:https://doi.org/10.3390/books978-3-03897-835-0 ISBN 978-3-03897-834-3 (Pbk); ISBN 978-3-03897-835-0 (PDF)

寄稿，Proceedings，報告書等書

  1. 伊東秀之，ザクロに含まれるエラジタンニンの構造とその抗糖化作用，Chromatography，40 (S1), p.9 (2019).

教科書

  1. 篠田純男, 三好伸一, 伊東秀之, 水野環（2019）人間と環境, 三共出版

2018

論文

（*Corresponding author）

  1. Nitta, Y., Yoshimura, Y., Ganeko, N., Ito, H., Okushima, N., Kitagawa, K., and Nishinari, K. (2018) Utilization of Ca2+-induced setting of alginate or low methoxyl pectin for noodle production from Japonica rice, LWT-Food Sci. Technol., 97, 362-369. https://doi.org/10.1016/j.lwt.2018.07.027
  2. Bastian, F., Ito, Y., Ogahara, E., Ganeko, N., Hatano, T., and Ito, H.* (2018) Simultaneous quantification of ellagitannins and related polyphenols in Geranium thunbergii using quantitative NMR, Molecules, 23 (6), 1346. https://doi.org/10.3390/molecules23061346
  3. Nagano, T., Ito, H. (2018) Diet containing a polyphenol concentrate from pomegranate juice attenuates contact hypersensitivity in mice, J. Funct.Foods, 45, 247-253. https://doi.org/10.1016/j.jff.2018.04.038
  4. Iwaoka, Y., Nishino, K., Ishikawa, T., Ito, H., Sawa, Y., and Tai, A. (2018) Affinity resins as new tools for identifying target proteins of ascorbic acid, Analyst, 143, 874-882. DOI: 10.1039/c7an01592e
  5. Miura, K., Haraguchi, M., Ito, H., and Tai, A.(2018) Potential antitumor activity of 2-O-α-D-glucopyranosyl-6-O-(2-pentylheptanoyl)-L-ascorbic acid, Int. J. Mol. Sci., 19 (2), 535. doi:10.3390/ijms19020535
  6. Nagano, T., Nishida, N., and Ito, H. (2018) The inhibitory effect of a polyphenol concentrate from pomegranate juice on 2,4-dinitrofluorobenzene-induced contact hypersensitivity in mice, Food Sci. Technol. Res., 24 (1), 169-175. doi: 10.3136/fstr.24.169

2017

論文

（*Corresponding author）

  1. Miura, K., Morishita, Y., Matsuno, H., Aota, Y., Ito, H., and Tai, A. (2017) Anti-Allergic Activity of Monoacylated Ascorbic Acid 2-Glucosides, Molecules, 22(12), 2202. doi:10.3390/molecules22122202
  2. Tai, A., Iomori, A., Ito, H. (2017) Structural evidence for the DPPH radical-scavenging mechanism of 2-O-α-D-glucopyranosyl-L-ascorbic acid, Bioorg. Med. Chem., 25(20), 5303-5310. https://doi.org/10.1016/j.bmc.2017.07.044
  3. Kim, T.H., Hatano, T., Okamoto, K., Yoshida, T., Kanzaki, H., Arita, M., and Ito, H.* (2017) Antifungal and Ichthyotoxic Sesquiterpenoids from Santalum album Heartwood, Molecules, 22(7), 1139. doi:10.3390/molecules22071139
  4. Kato, N., Kawabe, S., Ganeko, N., Yoshimura, M., Amakura, Y., and Ito, H.* (2017) Polyphenols from flowers of Magnolia coco and their anti-glycation effects, Biosci. Biotech. Biochem., 81(7), 1285-1288. http://dx.doi.org/10.1080/09168451.2017.1292837
  5. Kawabe, S., Ganeko, N., and Ito, H.* (2017) Ellagitannin Dimers from Pericarps of Trapa japonica, The Japanese Journal of Pharmacognosy, 71 (1), 53-54.

特許出願

  1. 『終末糖化産物生成抑制剤』
    特願2017-060189
    出願日：平成29年3月24日
    発明者：伊東　秀之，山田 道生，竹下　祥子，上村　知広
    特許出願人：林兼産業株式会社，公立大学法人岡山県立大学

2016

論文

（*Corresponding author）

  1. Tai, A., Ohno, A., and Ito, H. (2016) Isolation and Characterization of the 2,2′-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) Radical Cation-Scavenging Reaction Products of Arbutin, J. Agric. Food Chem., 64 7285-7290, DOI: 10.1021/acs.jafc.6b02847
  2. Zhao, C., Sakaguchi, T., Fujita, K., Ito, H., Nishida, N., Nagatomo, A., Tanaka-Azuma, Y., and Katakura, Y. (2016) Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation, Oxid. Med. Cell Longev., 2016 Article ID 2927131, 9 pages, http://dx.doi.org/10.1155/2016/2927131
  3. Ishimata, N., Ito, H., Tai, A. (2016) Structure–activity relationships of vanillic acid ester analogs in inhibitory effect of antigen-mediated degranulation in rat basophilic leukemia RBL-2H3 cells, Bioorg. Med. Chem. Lett., 26 3533-3536, DOI: 10.1016/j.bmcl.2016.06.028
  4. Morita,A., Tai, A., Ito, H., Ganeko, N., and Aizawa, S-I. (2016)Proanthocyanidins in an astringent persimmon inhibit Salmonella pathogenicity island 1 (SPI1) secretion, J. Sci. Food Agric., 96 (5) 1798-1802, DOI:10.1002/jsfa.7289

総説，著書

（*Corresponding author）

  1. 伊東秀之 (2016) エラジタンニンの生体内挙動とその代謝産物の機能性，ポリフェノール：機能性成分研究開発の最新動向，Polyphenols : New Trends of Studies and Developments on Functional Constituents in Plants，監修：波多野力，下田博司，シーエムシー出版，37-44.

寄稿，Proceedings，報告書等書

  1. 伊東秀之，機能性ポリフェノールの生体利用性，川崎医学会誌，42-補遺号，S17, 2016.

特許

  1. 『ビフィズス菌または乳酸菌の生存維持用組成物』
    特許第5943406号（特願2011-090684）
    登録日：平成28年6月3日
    出願日：平成23年4月15日
    発明者：伊東　秀之，西田 典永，長友 暁史，吉野 智恵，小崎 敏雄
    特許出願人：森下仁丹株式会社，国立大学法人岡山大学

特許出願

  1. 『米粉麺の製造方法』
    特願2016-017861
    出願日：平成28年2月2日
    発明者：奥島　信行，北川　昌昭，木津　陽子，伊東　秀之，辻　英明
    特許出願人：奥島信行，北川昌昭，岡山県新規需要米生麺協同組合，公立大学法人岡山県立大学
  2. 『ウロリチン類を含有する育毛剤、及び、ウロリチン類を含有する５αレダクターゼ活性阻害剤』
    特願2016-043743
    出願日：平成28年3月7日
    発明者：矢ヶ崎 秀雄，中島 賢則，山本 浩明，伊東　秀之
    特許出願人：公立大学法人岡山県立大学，株式会社ダイセル

2015

論文

（*Corresponding author）

  1. Yagi,M., Mitsuhashi, R., Watanabe, A., Moritani, Y., Naito, J., Lanny, P., Ito,H., Nagatomo, A., Nishida, N., Yonei, Y. (2015) Cleaving effect ofpomegranate (Punica granatum) extracton crosslink derived from advanced glycation endproducts, Glycative Stress Res., 2 (2), 58-66. http://www.toukastress.jp/webj/article/2015/GS15-11.pdf
  2. Takahashi,Y., Otsuki, A., Mori, Y., Kawakami, Y., and Ito, H. (2015) Inhibition ofleukocyte-type 12-lipoxygenase by guava tea leaves prevents development ofatherosclerosis, Food Chem., 186, 2-5.DOI:10.1016/j.foodchem.2015.03.105

寄稿，Proceedings，報告書等書

  1. 伊東秀之，トキワレンゲのポリフェノール成分と機能性，川崎医学会誌，41-補遺号，S75, 2015.

特許出願

  1. 『ウロリチン類を含有する、抗しわ剤、コラーゲン産生促進剤、ＭＭＰ－１産生抑制剤、及びエラスターゼ活性阻害剤』
    特願2015-153959
    出願日：平成27年8月4日
    発明者：矢ヶ崎 秀雄，中島 賢則，山本 浩明，伊東　秀之
    特許出願人：公立大学法人岡山県立大学，株式会社ダイセル
  2. 『ウロリチン類を含有するメラニン産生抑制剤』
    特願2015-136145
    出願日：平成27年7月7日
    発明者：矢ヶ崎 秀雄，中島 賢則，山本 浩明，伊東　秀之
    特許出願人：公立大学法人岡山県立大学，株式会社ダイセル
  3. 『ウロリチン類を含有するヒアルロン酸産生促進剤』
    特願2015-132903
    出願日：平成27年7月1日
    発明者：矢ヶ崎 秀雄，中島 賢則，山本 浩明，伊東　秀之
    特許出願人：公立大学法人岡山県立大学，株式会社ダイセル
  4. 『ウロリチンを含有する光老化抑制剤』
    特願2015-121836
    出願日：平成27年6月17日
    発明者：矢ヶ崎 秀雄，中島 賢則，山本 浩明，伊東　秀之
    特許出願人：公立大学法人岡山県立大学，株式会社ダイセル
  5. 『ウロリチン類を含有する抗糖化剤』
    特願2015-099927
    出願日：平成27年5月15日
    発明者：矢ヶ崎 秀雄，中島 賢則，山本 浩明，伊東　秀之
    特許出願人：公立大学法人岡山県立大学，株式会社ダイセル

2014

論文

（*Corresponding author）

  1. Kurasawa,Y., Yoshida, K., Yamazaki, N., Sasaki, K., Zamami, Y., Min, Z., Togi, A., Ito,H., Kaji, K., and Fukuya, H. (2014) Quinolone analogues 16: A facile D–H exchange for 3-H proton of 2-substituted 4-quinolones in acidicmedia, J. Heterocyclic Chem., 51 (6), 1821-1829. DOI:10.1002/jhet.1933
  2. Kurasawa,Y., Yoshida, K., Yamazaki, N., Sasaki, K., Zamami, Y., Min, Z., Togi, A., Ito,H., Kaji, K., and Fukuya, H. (2014) Quinolone analogues 15: Synthesis andantimalarial activity of4-phenyl-1-(1-triazolylmethyl-4-quinolon-3-ylcarbonyl)semicarbazide and relatedcompounds, J. Heterocyclic Chem., 51 (S1), E249-E254. DOI:10.1002/jhet.1822
  3. Kurasawa,Y., Yoshida, K., Yamazaki, N., Sasaki, K., Zamami, Y., Min, Z., Togi, A., Ito,H., Kaji, K., and Fukuya, H. (2014) Quinolone analogues 14: Synthesis ofantimalarial 1-aryl-3-(4-quinolon-2-yl)ureas and related compounds, J. Heterocyclic Chem., 51 (S1), E241-E248. DOI:10.1002/jhet.1813
  4. Kurasawa,Y., Yoshida, K., Yamazaki, N., Sasaki, K., Zamami, Y., Min, Z., Togi, A., Ito,H., Kaji, K., and Fukuya, H. (2014) Quinolone analogues 13: Synthesis ofnovel 1,1′-(2-methylenepropane-1,3-diyl)di(4-quinolone-3-carboxylate) andrelated compounds, J. Heterocyclic Chem., 51 (6), 1720-1726. DOI: 10.1002/jhet.1861
  5. Tai,A., Aburada, M., Ito, H. (2014) A simple efficient synthesis andbiological evaluation of 3-O-ethylascorbicacid, Biosci. Biotech. Biochem., 78 (12), 1984-1987.http://dx.doi.org/10.1080/09168451.2014.946396
  6. Tai,A., Fukunaga, K., Ohno, A., Ito, H. (2014) Antioxidative properties ofascorbigen in using multiple antioxidant assays, Biosci. Biotech. Biochem., 78 (10), 1723-1730. http://dx.doi.org/10.1080/09168451.2014.932668
  7. Kawakami,K., Li, P., Uraji, M., Hatanaka, T., Ito, H.* (2014) Inhibitory effectsof pomegranate extracts on recombinant human maltase-glucoamylase, J. Food Sci., 79 (9) 1848-1852. DOI: 10.1111/1750-3841.12568
  8. Asano,R., Nagami, A., Fukumoto, Y., Miura, K., Yazama, F., Ito, H., Sakata,I., Tai, A. (2014) Synthesis and biological evaluation of new BSH-conjugatedchlorin derivatives as agents for both photodynamic therapy and boron neutroncapture therapy of cancer, J. Photochem.Photobiol., B., 140, 140-149.DOI: 10.1016/j.jphotobiol.2014.07.008
  9. Ikeguchi,M., Tsubata, M., Takano, A., Kamiya, T., Takagaki, K., Ito, H.,Sugawa-Katayama Y., and Tsuji, H. (2014) Effects of young barley leaf powder ongastrointestinal functions in rats and its efficacy-related physicochemicalproperties, Evid. Based Complement.Alternat. Med., 2014, Article ID974840, 7 pages. http://dx.doi.org/10.1155/2014/974840
  10. Arunrattiyakorn,P., Suwannasai, N., Aree, T., Kanokmedhakul, S., Ito, H., Kanzaki, H.(2014) Biotransformation of α-mangostin by Colletotrichum sp. MT02 and Phomopsiseuphorbiae K12, J. Mol. Catal. B:Enzym., 102, 174-179.http://dx.doi.org/10.1016/j.molcatb.2014.02.010
  11. Asano,R., Nagami, A., Fukumoto, Y., Miura, K., Yazama, F., Ito, H., Sakata,I., Tai, A. (2014) Synthesis and biological evaluation of new boron-containingchlorin derivatives as agents for both photodynamic therapy and boron neutroncapture therapy of cancer, Bioorg. Med.Chem. Lett., 24, 1339-1343.http://dx.doi.org/10.1016/j.bmcl.2014.01.054
  12. Ito,H.,* Li, P., Koreishi, M., Nagatomo, A., Nishida, N.,and Yoshida, T. (2014) Ellagitannin oligomers and a neolignan from pomegranatearils and their inhibitory effects on the formation of advanced glycation endproducts, Food Chem., 152, 323-330.http://dx.DOI.org/10.1016/j.foodchem.2013.11.160
  13. Kawasaki,T., Ito, H., Omote, H. (2014) Components of Foods Inhibit a DrugExporter, Human Multidrug and Toxin Extrusion Transporter 1, Biol. Pharm. Bull., 37 (2), 292-297. http://dx.doi.org/10.1248/bpb.b13-00815
    ★Highlightedpaper selected by Editor-in-Chief に選ばれました

総説，著書

（*Corresponding author）

  1. 伊東秀之* (2014) 加水分解性ポリフェノール，エラジタンニンの生体内代謝産物とその機能，バイオサイエンスとインダストリー，72 (2), 123-124.

寄稿，Proceedings，報告書等書

  1. 伊東秀之，有色米のポリフェノール成分とその機能性に関する研究，平成26年度年報　財団法人　飯島藤十郎記念食品科学振興財団，第30巻，204-210 (2014).
  2. 伊東秀之，エラジタンニンの体内動態および抗炎症作用に関する研究，日本食品科学研究振興財団第20回研究成果報告書，107-110 (2014).
  3. Mao Kanada, Peng Li, Akifumi Nagatomo, Norihisa Nishida, Yoichi Matsuura, Natsuki Ganeko and Hideyuki Ito, New ellagitannin oligomers and related polyphenols from pomegranate arils and their inhibition of AGEs formation, Polyphenols Communications 2014, 613-614.
  4. Hideyuki Ito and Erika Ogahara, Simultaneous quantification of ellagitannins and related polyphenols in Geranium thunbergii and pomegranate by quantitative NMR, Polyphenols Communications 2014, 611-612.
  5. Natsuki Ganeko and Hideyuki Ito, Constituents of skins and beards of red-kerneled rice, Polyphenols Communications 2014, 417-418.
  6. Sayuri Yamaguchi, Tsukasa Hirokane, Takashi Yoshida, Takashi Tanaka, Tsutomu Hatano, Hideyuki Ito, Gen-ichiro Nonaka, and Hidetoshi Yamada, Roxbin B is cuspinin: Structural revision and total synthesis, Polyphenols Communications 2014, 145-146.

2013

論文

（*Corresponding author）

  1. Tominaga,H., Ishihara, T., Shah, A.K.M.A., Shimizu, R., Onyango, A.N., Ito, H.,Suzuki, T., Kondo, Y., Koaze, H., Takahashi, K., Baba, N. (2013) Molecularprobes in tandem electrospray ionization mass spectrometry: Application totracing chemical changes of specific phospholipid molecular species, Am. J. Anal. Chem., 4 (10B), 16-26. DOI: 10.4236/ajac.2013.410A2003
  2. Kwon,O. J., Bae, J.-S., Lee, H. Y., Hwang, J.-Y., Lee, E.-W., Ito, H., andKim, T. H. (2013) Pancreatic lipase inhibitory gallotannins from Galla rhois with inhibitory effects onadipocyte differentiation in 3T3-L1 cells, Molecules, 18, 10629-10638.DOI:10.3390/molecules180910629
  3. Yamaguchi,S., Hirokane, T., Yoshida, T., Tanaka, T., Hatano, T., Ito, H., Nonaka,G., and Yamada, H., (2013) Roxbin B is cuspinin: Structural revision and totalsynthesis, J. Org. Chem., 78, 5410-5418. DOI: 10.1021/jo400562k
  4. Ito,H.,* Otsuki, A., Mori, H., Li, P., Kinoshita, M.,Kawakami, Y., Tsuji, H., Fang, D.Z., Takahashi, Y. (2013) Two new monoterpeneglycosides from Qing Shan Lu Shui tea with inhibitory effects on leukocyte-type12-lipoxygenase activity, Molecules, 18, 4257-4266. DOI:10.3390/molecules18044257
  5. Tai,A., Iwaoka, Y., Ito, H. (2013) Highly efficient and regioselectiveproduction of an erythorbic acid glucoside using cyclodextringlucanotransferase from Thermoanaerobacter sp. and amyloglucosidase, J. Mol. Catal.B Enzym., 92, 19-23.http://dx.doi.org/10.1016/j.molcatb.2013.03.011
  6. Asano,R., Nagami, A., Fukumoto, Y., Yazama, F., Ito, H., Sakata, I., Tai, A.(2013) Synthesis and biological evaluation of new chlorin derivatives aspotential photosensitizers for photodynamic therapy, Bioorg. Med. Chem., 21,2298-2304. http://dx.doi.org/10.1016/j.bmc.2013.02.005
  7. Waha,L.K., Abasb, F., Cordelld G.A., Ito, H., and Ismail I.S. (2013) Steroidsfrom Dysoxylum grande (Meliaceae)leaves, Steroids, 78, 210-219.http://dx.doi.org/10.1016/j.steroids.2012.09.011

寄稿，Proceedings，報告書等書

  1. 伊東秀之，エラジタンニンの体内動態および抗炎症作用に関する研究，日本食品科学研究振興財団第19回研究成果報告書，92-95 (2013).
  2. 田井章博, 岩岡裕二, 伊東秀之 (2013) シクロデキストリングルカノトランスフェラーゼとアミログルコシダーゼを用いた高効率的かつ位置選択的なエリソルビン酸グルコシドの合成，ビタミン，87 (7), 364-366.
  3. 田井 章博, 岩岡 裕二, 伊東 秀之 (2013) 高分子触媒によるDMF中アスコルビン酸2-グルコシドの部位選択的モノアシル化，ビタミン，87 (3), 154-155.

特許出願

  1. 『メイラード反応阻害剤』
    特願2013-223611
    出願日：平成25年10月28日
    発明者：西田 典永，長友 暁史，伊東　秀之
    特許出願人：森下仁丹株式会社

2012

論文

（*Corresponding author）

  1. Taniguchi,S., Nogaki, R., Bao, L-M., Kuroda, T., Ito, H., and Hatano, T. (2012)Furosonin, a novel hydrolyzable tannin from Geraniumthunbergii, Heterocycles, 86 (2), 1525-1532.
  2. Nagano,T., Ito, H., and Okamoto, T. (2012) Inhibitory effect of ellagitanninmetabolites on IgE-mediated allergic responses in RBL-2H3 cells, Biosci. Biotech. Biochem., 76 (12), 2310-2312.http://dx.doi.org/10.1271/bbb.120448
  3. Kirino,A., Takasuka, Y, Nishi, H., Kawabe, S., Yamashita, H., Kimoto, M., Ito, H.,and Tsuji, H. (2012) Analysis and functionality of major polyphenoliccomponents of Polygonum cuspidatum (Itadori), J. Nutr. Sci. Vitaminol., 58 (4), 278-286.http://dx.doi.org/10.3177/jnsv.58.278
  4. Kurasawa,Y., Yoshida, K., Yamazaki, N., Kaji, E., Sasaki, K., Zamami, Y., Sakai, Y.,Fujii, T., and Ito, H. (2012) Quinolone analogs 11: Synthesis of novel4-quinolone-3-carbohydrazide derivatives with antimalarial activity, J. Heterocyclic Chem., 49 (2), 288-292. DOI: 10.1002/jhet.774
  5. Tai,A., Ikeda, S., Yazama, F., and Ito, H. (2012) Intramolecular acylmigration and enzymatic hydrolysis of 2-O-α-D-glucopyranosyl-6-O-(2-pentylheptanoyl)-L-ascorbicacid, J. Biosci. Bioeng., 113 (4), 545-548.http://dx.doi.org/10.1016/j.jbiosc.2011.11.023
  6. Ishimoto,H., Tai, A., Yoshimura, M., Amakura, Y., Yoshida, T., Hatano, T., and Ito,H.* (2012) Antioxidative properties of functional polyphenols and theirmetabolites assessed by an ORAC assay, Biosci.Biotech. Biochem., 76 (2),395-399. http://dx.doi.org/10.1271/bbb.110717
  7. Tai,A., Sawano, T., Ito, H. (2012) Antioxidant properties of vanillic acidesters in multiple antioxidant assays, Biosci.Biotech. Biochem., 76 (2),314-318. http://dx.doi.org/10.1271/bbb.110700
  8. Bao,L.-M., Eerdunbayaer, Nozaki, A., Takahashi, E., Okamoto, K., Ito, H.,and Hatano, T. (2012) Hydrolysable tannins isolated from Syzygium aromaticum: Structure of a new C-glucosidic ellagitannin and spectral features of tannins with atergalloyl group, Heterocycles, 85, 365-381.

特許出願

  1. 『新規化合物』
    特願2012-163826
    出願日：平成24年7月24日
    発明者：波多野 力，谷口 抄子，伊東　秀之，岸田 啓治，伊神 孝生，斎藤 衛郎，若泉 賢功，川路 美由紀，藤井 孝，奥田 貴博
    特許出願人：三基商事株式会社，国立大学法人岡山大学
  2. 『新規化合物』
    特願2012-163824
    出願日：平成24年7月24日
    発明者：波多野 力，谷口 抄子，伊東　秀之，岸田 啓治，伊神 孝生，斎藤 衛郎，若泉 賢功，川路 美由紀，藤井 孝，奥田 貴博
    特許出願人：三基商事株式会社，国立大学法人岡山大学

2011

論文

（*Corresponding author）

  1. Tai,A., Iwaoka, Y., Ito, H. (2011) Regioselective monoacylation of 2-O-α-D-glucopyranosyl-L-ascorbicacid by a polymer catalyst in N,N-dimethylformamide, Carbohydr. Res., 346, 2511-2515. http://dx.doi.org/10.1016/j.carres.2011.08.010
  2. Ishimoto,H., Shibata, M., Myojin, Y., Ito, H.,* Sugimoto, Y., Tai, A, Hatano, T.(2011) In vivo anti-inflammatory and antioxidant properties of ellagitanninmetabolite urolithin A, Bioorg. Med.Chem. Lett., 21 (19), 5901-5904.http://dx.doi.org/10.1016/j.bmcl.2011.07.086
  3. Onoue,S., Seto, Y., Ochi, M., Inoue, R., Ito, H., Hatano, T., Yamada, S.(2011) In vitro photochemical andphototoxicological characterization of major constituents in St. John’s Wort (Hypericum perforatum) extracts, Phytochemistry, 72, 1814-1820. http://dx.doi.org/10.1016/j.phytochem.2011.06.011
  4. Ohyabu,T., Taniguchi, S., Ito, H., and Hatano, T. (2011) New oxidation productsfrom (-)-epigallocatechin gallate in neutral solution, Heterocycles, 82 (2),1685-1692.
  5. Kim,T.-H., Kim, J. K., Ito, H., and Jo, C. (2011) Enhancement of pancreaticlipase inhibitory activity of curcumin by radiolytic transformation, Bioorg. Med. Chem. Lett., 21, 1512-1514.http://dx.doi.org/10.1016/j.bmcl.2010.12.122
  6. González-Barrio,R., Truchado, P., Ito, H., Espín, J.C., Tomás-Barberán, F.A. (2011) UVand MS identification of urolithins and nasutins, the bioavailable metabolitesof ellagitannins and ellagic acid in different mammals, J. Agric. Food. Chem., 59,1152-1162. DOI: 10.1021/jf103894m
  7. Tai,A., Sawano, T., Yazama, F., and Ito, H. (2011) Evaluation of antioxidantactivity of vanillin by using multiple antioxidant assays, Biochim. Biophys. Acta-General Subjects, 1810, 170-177. http://dx.doi.org/10.1016/j.bbagen.2010.11.004

総説，著書

（*Corresponding author）

  1. Ito, H.* (2011) Metabolites of the ellagitannin geraniin and their antioxidant activities, Planta Medica, 11 (77), 1110-1115. DOI: 10.1055/s-0030-1264186
  2. Okuda, T., Ito, H., (2011) Tannins of constant structure in medicinal and food plants—Hydrolyzable tannins and polyphenols related to tannins, Molecules, 16 (3), 2191-2217. DOI:10.3390/molecules16032191

特許出願

  1. 『ビフィズス菌または乳酸菌の生存維持用組成物』
    特願2011-090684
    出願日：平成23年4月15日
    発明者：伊東　秀之，西田 典永，長友 暁史，吉野 智恵，小崎 敏雄
    特許出願人：森下仁丹株式会社

2010

論文

（*Corresponding author）

  1. Kimura,Y., Ito, H.,* Hatano, T. (2010) Effects of Mace and Nutmeg on HumanCytochrome P450 3A4 and 2C9 Activity, Biol.Pharm. Bull., 33 (12),1977-1982. http://dx.doi.org/10.1248/bpb.33.1977
  2. Tai,A., Iwaoka, Y., Mori, T., Ito, H. (2010) Protease-catalyzedmonoacylation of 2-O-α-D-glucopyranosyl-L-ascorbic acid in three solvent systems, Biosci. Biotech. Biochem., 74 (9), 1969-1971.http://dx.doi.org/10.1271/bbb.100362
  3. Tai,A., Mori, T., Urushihara, M., Ito, H., Kawasaki, D., Yamamoto, I. (2010)Intramolecular acyl migration and enzymatic hydrolysis of a novel monoacylatedascorbic acid derivative, 6-O-dodecanoyl-2-O-α-D-glucopyranosyl-L-ascorbicacid, Bioorg. Med. Chem., 18, 6179-6183. http://dx.doi.org/10.1016/j.bmc.2010.06.027
  4. 木村友香，伊東秀之*，波多野力（2010）天然添加物の薬物代謝酵素の作用に及ぼす影響，日本食品化学学会誌，17 (2), 97-101.
    ★日本食品化学学会第６回論文賞に選ばれました
  5. Tai,A., Mori, T., Kimura, Y., Ito, H. (2010) Monoacylation of 2-O-α-D-glucopyranosyl-L-ascorbicacid by protease in N,N-dimethylformamidewith low water content, Carbohydr. Res., 345 (12), 1658-1662.http://dx.doi.org/10.1016/j.carres.2010.04.028
  6. 野崎阿季子，高橋栄造，岡本敬の介，伊東秀之，波多野力 (2010) Candida 属真菌に対する各種精油及び精油成分の抗真菌作用，及びAmphotericin B の抗真菌作用に及ぼす影響，薬学雑誌，130 (6), 895-902.
  7. Kurasawa,Y., Yoshida, K., Yamazaki, N., Kaji, E., Sasaki, K., Hiwasa, Y., Tsukamoto, A., Ito, H. (2010) Quinolone analogues 10: Synthesis of antimalarialquinolones having pyridyl moiety in N1-side chain, J. Heterocyclic Chem., 47 (3), 657-663. DOI: 10.1002/jhet.297
  8. Kimura,Y., Ito, H.,* Ohnishi, R., and Hatano, T. (2010) Inhibitory effects ofpolyphenols on human cytochrome P450 3A4 and 2C9 activity, Food Chem. Toxicol., 48 (1), 429-435. http://dx.doi.org/10.1016/j.fct.2009.10.041
  9. Fukuda,K., Tamura, T., Ito, H., Yamamoto, S., Ochi, K., and Inagaki, K. (2010)Production improvement of antifungal, antitrypanosomal nucleoside sinefungin byrpoB mutation and optimization of resting cell system of Streptomyces incarnatus NRRL 8089, J. Biosci. Bioeng., 109 (5), 459-465. http://dx.doi.org/10.1016/j.jbiosc.2009.10.017

寄稿，Proceedings，報告書等書

  1. Ito, H., Sun, X.-L., Watanabe, M., Okamoto, M., and Hatano, H., Neurotrophic Activity of Polyphenols and Related Compounds Using Primary Cultures of Fetal Rat Hippocampal Neurons, Polyphenols Communications 2010, 2, 399 (2010).
  2. Kimura, Y., Ito, H., Ohnishi, R., Sasaki, N., Kariyama, R., Mitsuhata, R., Kumon, H., Kaneda, M., Yoshida, T., and Hatano, T., Urinary Metabolites of Cranberry Polyphenols in Human and Their Inhibitory Effects on Biofilm Formation by Escherichia coli, Polyphenols Communications 2010, 2, 404-405 (2010).
  3. Uchimura, T., Ito, H., Maeda, N., Totsuka, M., Shimizu, M., and Hatano, T., The Effect of Phytochemicals on the IgA Production by Murine Peyer’s Patch Cells, Polyphenols Communications 2010, 2, 363-364 (2010).
  4. Kimura, Y., Sasaki, N., Ito, H., Hatano, T., Investigation on possible interaction of cranberry polyphenols and warfarin using in vitro and in vivo studies, Planta Medica, 76 (12), 1216 (2010).
  5. Ito, H., Metabolites of ellagitannins and their antioxidant activity, Planta Medica, 76 (12), 1165 (2010).
  6. 田井章博, 森佑, 木村友香, 伊東秀之 (2010) 少量の水を含むDMF中におけるアスコルビン酸2‐グルコシドのプロテアーゼによるモノアシル化，ビタミン，84(11), 548-549.
  7. 田井章博, 森佑, 漆原将也, 伊東秀之, 川崎大輔, 山本格 (2010) 新規モノアシル化アスコルビン酸誘導体6‐O‐dodecanoyl‐2‐O‐α‐D‐glucopyranosyl‐L‐ascoribic acidの分子内アシル基転位と酵素的加水分解，ビタミン, 84(11), 550-551.
  8. 伊東秀之，腸管免疫強化作用を有する機能性穀類成分の探索，平成２０年度年報　財団法人　飯島記念食品科学振興財団研究報告書，230-234 (2010).

教科書

  1. 伊東秀之, 高橋吉孝, 辻英明, 中島伸佳, 山本登志子（2010）栄養科学NEXTシリーズ　基礎有機化学, 高橋吉孝, 辻英明編, 講談社サイエンティフィク
  2. 雨谷栄，飯塚徹，石毛敦，伊東秀之，大泉康，金成俊，小松健一，白瀧義明，関隆志，寺林進，南雲清二，西村甲，野村靖幸（2010）漢方医療薬学の基礎，野村靖幸編集，廣川書店．

2009

論文

（*Corresponding author）

  1. 山中文，波多野力，伊東秀之，谷口抄子，高橋栄造，岡本敬の介（2009）グァバ飲料およびグァバ葉に含まれるタンニンおよび関連ポリフェノールの食中毒細菌に対する抗菌作用，機能性食品と薬理栄養，5 (4), 217-222.
  2. Nozaki,A., Kimura, T., Ito, H., and Hatano, T. (2009) Interaction ofpolyphenolic metabolites with human serum albumin: A circular dichroism study, Chem. Pharm. Bull., 57 (9), 1019-1023.
  3. Kumura,N., Furukawa, H., Onyangob, A.N. Izumia, M., Nakajima, S., Ito, H.,Hatano, T., Kim, H.-S., Wataya, Y., and Baba, N. (2009) Different behavior ofartemisinin and tetraoxane in the oxidative degradation of phospholipid, Chem. Phys. Lipids, 160 (2), 114-120. http://dx.doi.org/10.1016/j.chemphyslip.2009.04.005
  4. Shimoda,H,, Tanaka, J., Kikuchi, M., Fukuda, T., Ito, H., Hatano, T. andYoshida, T. (2009) Effect of Polyphenol-Rich Extract from Walnut onDiet-Induced Hypertriglyceridemia in Mice via Enhancement of Fatty AcidOxidation in the Liver, J. Agric. FoodChem., 57 (5), 1786-1792. DOI:10.1021/jf803441c
  5. Nozaki,A., Hori, M., Kimura, T., Ito, H., and Hatano, T. (2009) Interaction ofpolyphenols with proteins: Binding of (-)-epigallocatechin gallate to serumalbumin, estimated by induced circular dichroism, Chem. Pharm. Bull., 57 (2), 224-228.
  6. Farag,S.F., Kimura, Y., Ito, H.,* Takayasu, J., Tokuda, H. and Hatano, T.(2009) New isoflavone glycosides from Irisspuria L. (Calizona) cultivated in Egypt, J. Nat. Med., 63 (1), 91-95. DOI: 10.1007/s11418-008-0291-7

総説，著書

（*Corresponding author）

  1. Okuda, T., Yoshida, T., Hatano, T., and Ito, H. (2009) Ellagitannins renewed the concept of tannins, Edited by Quideau, S., Chemistry and biology of ellagitannins –An underestimated class of bioactive plant polyphenols-, World Scientific, Singapore, 1-54. DOI:10.1142/9789812797414_0001
  2. Yoshida, T., Hatano, T., Ito, H., and Okuda, T. (2009) Structural diversity and antimicrobial activities of ellagitannins, Edited by Quideau, S., Chemistry and biology of ellagitannins –An underestimated class of bioactive plant polyphenols-, World Scientific, Singapore, 55-93. DOI: 10.1142/9789812797414_0002

寄稿，Proceedings，報告書等書

  1. 伊東秀之，天然添加物の薬物代謝酵素の作用に及ぼす影響に関する基礎研究，日本食品科学研究振興財団第15回研究成果報告書，105-110 (2009).
  2. 伊東秀之，香辛料食品と医薬品との相互作用に関する基礎研究，浦上財団研究報告書，No.16, 165-171（2009）.

特許出願

  1. 『トリプターゼ活性阻害剤およびその利用』
    特願2009-207609
    出願日：平成21年9月9日
    発明者：小島 弘之，アルナシリ イダマルゴダ，波多野 力，伊東　秀之
    特許出願人：一丸ファルコス株式会社

2008

論文

（*Corresponding author）

  1. Yoshimura,M., Ito, H., Miyashita, K., Hatano, T., Taniguchi, S., Amakura, Y., andYoshida, T. (2008) Flavonol glucuronides and C-glucosidic ellagitannins from Melaleuca squarrosa, Phytochemistry, 69 (18), 3062-3069.http://dx.doi.org/10.1016/j.phytochem.2008.04.004
  2. Yoshida,T., Ito, H., Yoshimura, M., Miyashita, K., and Hatano, T. (2008) C-Glucosidicellagitannin oligomers from Melaleuca squarrosa Donn ex Sm., Myrtaceae, Phytochemistry, 69 (18), 3070-3079.http://dx.doi.org/10.1016/j.phytochem.2007.07.002
  3. Kasajima,N., Ito, H.,* Hatano, T., and Yoshida, T. (2008) Phloroglucinoldiglycosides accompanying hydrolyzable tannins from Kunzea ambigua, Phytochemistry, 69 (18), 3080-3086.http://dx.doi.org/10.1016/j.phytochem.2008.03.003
  4. Shimoda,H., Tanaka, J., Kikuchi, M., Fukuda, T., Ito, H., Hatano, T., andYoshida, T., (2008) Walnuts polyphenols prevent liver damage induced by carbontetrachloride and D-galactosamine: hepatoprotective hydrolyzable tannins in thekernel of walnuts, J. Agric. Food Chem., 56 (2), 4444-4449. DOI:10.1021/jf8002174
  5. Kimura,Y., Ito, H.,* Kawaji, M., Ikami, T., and Hatano, T. (2008) Characterization and antioxidantproperties of oligomeric proanthocyanidin from prunes, dried fruits of Prunus domestica L., Biosci. Biotech. Biochem., 72 (6), 1615-1618.http://dx.doi.org/10.1271/bbb.70823
  6. Yamanaka,F., Hatano, T., Ito, H., Taniguchi, S., Takahashi, E., and Okamoto, K.(2008) Antibacterial effects of Guava tannins and related polyphenols on Vibrio and Aeromonas species, Nat. Prod.Comm. 3 (5), 711-720.
  7. Mennen,L.I., Sapinho, D., Ito, H., Galan, P., Hercberg, S., Scalbert, A. (2008)Urinary excretion of thirteen dietary flavonoids and phenolic acids infree-living healthy subjects – Variability and possible use as biomarkers of polyphenol intake, Eur. J. Clin. Nutr., 62 (4), 519-525.DOI:10.1038/sj.ejcn.1602744
  8. Ito,H.,* Sun, X.-L., Watanabe,M., Okamoto, M. and Hatano, T. (2008) Chlorogenic acid and its metabolite m-coumaric acid evoke neurite outgrowthin hippocampal neuronal cells, Biosci.Biotech. Biochem., 72 (3),885-888. DOI:10.1271/bbb.70670
  9. Ito,H.,* Iguchi, A., andHatano, T. (2008) Identification of urinary and intestinal bacterialmetabolites of ellagitannin geraniin in rats, J. Agric. Food Chem., 56 (2), 393-400. DOI: 10.1021/jf0726942

寄稿，Proceedings，報告書等書

  1. Ito, H., (2008) Metabolic fate of ellagitannins, The First Academic Meeting of Chinese Medicine Commodity, p. 422.
  2. 伊東秀之，天然添加物の薬物代謝酵素の作用に及ぼす影響に関する基礎研究，日本食品科学研究振興財団第14回研究成果報告書，83-87 (2008).

教科書

  1. 有澤宗久，池城安正，一柳孝司，伊東秀之，奥田純子，奥田拓男，北中進，高上馬希重，波多野力，福田直通，松崎桂一，米光美知子，（2008）最新薬用植物学，奥田拓男編，廣川書店．

2007

論文

（*Corresponding author）

  1. Ismail, I. S., Ito, H., and Yoshida, T. (2007) An ichthyotoxic procyanidin oligomer and four new hydroxyl acid conjugates from the leaves of Sandoricum koetjape, ACGC Chem. Res. Comm., 21, 13-19.
  2. Sun, X.-L., Ito, H., Masuoka, T., Kamei, C., and Hatano, T. (2007) Effect of Polygala tenuifolia root extract on scopolamine-induced impairment of rat spatial cognition in an eight-arm radial maze task, Biol. Pharm. Bull., 30 (9), 1727-1731.
  3. Jain, R., Jain, S., Sharma, A., Ito, H., Hatano, T. (2007) Isolation of (+)-pinitol and other constituents from the root bark of Tamarindus indica Linn., J. Nat. Med., 61, 355-356.
  4. 狩山玲子，大西令子，伊東秀之，吉田隆志，波多野力，苔口進，光畑律子，和田耕一郎，門田晃一，公文裕巳（2007）大腸菌性バイオフィルム形成抑制活性を有するクランベリー尿中代謝物の探索，Bacterial Adherence & Biofilm, 20, 129-133.
  5. Ito, H.,* Miyake, M., Nishitani, E., Miyashita, K., Yoshimura, M., Yoshida, T., Takasaki, M., Konoshima, T., Kozuka, M., and Hatano T. (2007) Cowaniin, a C-glucosidic ellagitannin dimer linked through catechin from Cowania mexicana, Chem. Pharm. Bull., 55 (3), 492-494.
  6. Ito, H.,* Okuda, T., Fukuda, T., Hatano, T., and Yoshida, T. (2007) Two novel dicarboxylic acid derivatives and a new dimeric hydrolyzable tannin from walnuts, J. Agric. Food Chem., 55 (3), 672-679.

寄稿，Proceedings，報告書等書

  1. Ito, H., Neurotrophic effects of food polyphenols (2007) Annual report of study for food under the supporting program by The SKYLARK Food Science Institute, No.20, 67-72.

教科書

  1. 市瀬浩志，伊東秀之，奥田順子，奥田拓男，笠井良次，木下武司，代田修，関田節子，田中斉，永津明人，波多野力，宮一諭起範，吉田隆志，渡邊敏子（2007）最新天然物化学，奥田拓男編，廣川書店．

2006

論文

（*Corresponding author）

  1. Ohnishi, R., Ito, H.,* Iguchi, A., Shinomiya, K., Kamei, C., Hatano, T., and Yoshida, T. (2006) Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice, Biosci. Biotech. Biochem., 70 (10), 2560-2563.
  2. Amakura, Y., Kondo, K., Akiyama, H., Ito, H., Hatano, T., Yoshida, T., and Maitani, T. (2006) Conjugated ketonic fatty acids from Pleurocybella porrigens, Chem. Pharm. Bull., 54 (8), 1213-1215.
  3. Amakura, Y., Kondo, K., Akiyama, H., Ito, H., Hatano, T., Yoshida, T., and Maitani, T. (2006) Characteristic long-chain fatty acid of Pleurocybella porrigens, J. Food Hyg. Soc. Japan, 47 (4), 178-181.
  4. Ohnishi, R., Ito, H.,* Kasajima, N., Kaneda, M., Kariyama R., Kumon, H., Hatano, T., and Yoshida, T. (2006) Urinary excretion of anthocyanins in human after cranberry juice ingestion, Biosci. Biotech. Biochem., 70 (7), 1681-1687.
    ＊FoodStyle21誌12月号の文献トピックスに紹介されました
  5. Mennen, L.I., Sapinho, D., Ito, H., Bertrais, S., Galan, P., Hercberg, S., and Scalbert, A. (2006) Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods, Br. J. Nutr., 96 (2), 191-198.
  6. Kim, T. H., Ito, H.,* Hatano, T., Takayasu, J., Tokuda, H., Nishino, H., Machiguchi, T., and Yoshida, T., (2006) New antitumor sesquiterpenoids from Santalum album of Indian origin, Tetrahedron, 62 (29), 6981-6989.

寄稿，Proceedings，報告書等書

  1. Ito, H. (2006) Hydrolyzable tannins from walnuts, Nutraceuticals and Functional Food for Healthy Aging, pp. 53-56.
  2. 伊東秀之 (2006) 大学・研究所めぐり（国立大学法人岡山大学大学院医歯薬学総合研究科），J. Jpn. Soc. Colour Mater.，79 (9), 419-420.

2005

論文

（*Corresponding author）

  1. Kim, T. H., Ito, H.,* Hatano, T., Hasegawa, T., Akiba, A., Machiguchi, T., Yoshida, T. (2005) Bisabolane- and Santalane-Type Sesquiterpenoids from Santalum album of Indian Origin, J. Nat. Prod., 68 (12), 1805-1808.
  2. Amakura, Y., Tsutsumi, T., Sasaki, K., Nakamura, M., Ito, H., Hatano, T., Yoshida, T., Maitani, T. (2005) Interaction of the aryl hydrocarbon receptor with several constituents from spinach and komatsuna extracts determined using in vitro bioassays, J. Health Sci., 51 (6) 715-719.
  3. Kolodziej, H., Burmeister, A., Trun, W., Radtke, O.A., Kiderlen, A.F., Ito, H., Hatano, T., Yoshida, T., and Foo, L.Y. (2005) Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells, Bioorg. Med. Chem., 13 (23), 6470-6476.
  4. Ito, H., Gonthier, M.P., Manach, C., Morand, C., Mennen, L., Remesy, C, and Scalbert, A. (2005) Polyphenol levels in human urine after intake of six different polyphenol-rich beverages, Br. J. Nutr., 94 (4), 500-509.
  5. Kasajima, N., Ito, H., Hatano, T., Yoshida, T., Kaneda, M. (2005) Cypellogins A, B and C, acylated flavonol glycosides from Eucalyptus cypellocarpa, Chem. Pharm. Bull. 53 (10), 1345-1347.
  6. Nomura, M., Tsukada, H., Ichimatsu, D., Ito, H., Yoshida, T. and Miyamoto, K. (2005) Inhibition of epidermal growth factor-induced cell transformation by tannins, Phytochemistry, 66 (17), 2038-2046.
  7. Yoshida, T., Ito, H., Jose H. Isaza, M. (2005) Pentameric ellagitannin oligomers in melastomataceous plants – chemotaxonomic significance, Phytochemistry, 66 (17), 1972-1983.
  8. Kim, T. H., Ito, H.,* Hayashi, K., Hasegawa, T., Machiguchi, T., Yoshida, T. (2005) Aromatic Constituents from the Heartwood of Santalum album L., Chem. Pharm. Bull., 53 (6), 641-644.
  9. Alam, A., Takaguchi, Y., Ito, H., Yoshida, T. and Tsuboi, S. (2005) Multi-functionalization of gallic acid towards improved synthesis of α- and β-DDB, Tetrahedron, 61 (7), 1909-1918.
  10. Ito, H., Yamada, Y., Kim, T.-H., Yoshida, T. (2005) Polyphenols from the leaves of Aronia melanocarpa, Natural Medicines, 59 (1), 52.
  11. Ismail, I.S., Ito, H., Selloum, L., Hammama, B., Yoshida, T. (2005) Constituents of Cleome arabica leaves and twigs, Natural Medicines, 59 (1), 53.

寄稿，Proceedings，報告書等書

  1. 伊東秀之 (2005) 三島海雲助成金報告書，42, 1-4.
  2. 伊東秀之 (2005) 平成１６年度財団法人農芸化学研究奨励会事業報告書，5-6．

総説，著書

（*Corresponding author）

  1. Sakagami, H., Chowdhury, S.A., Suzuki, F., Hashimoto, K., Hatano, H., Takekawa, F., Ishihara, M., Kikuchi, H., Nishikawa, H., Taniguchi, S., Ito, H., Hatano, T., Yoshida, T., Fukai, T., Shirataki, Y., Kawase, M., Watanabe, K., Mimaki, Y., Itoh, K., Horiuchi, A., Chai, W., Horiuchi, C.A., Motohashi, N. (2005) Tumor-specific cytotoxic activity of polyphenols, terpenoids, ketones and other synthetic compounds, Functional Polyphenols and Carotenes with Antioxidative Action, Edited by Motohashi, N. Research Signpost, Kerala, India, pp. 133-176.
  2. Yoshida, T., Hatano, T., Ito, H. (2005) High molecular weight plant polyphenols (Tannins): Prospective functions, J.T. Romeo (Ed.), Recent Advance in Phytochemistry, Vol. 39: Chemical Ecology and Phytochemistry of Forest Ecosystems, Elsevier Science, Amsterdam, pp. 163-190. 9. Sakagami, H., Hashimoto, K., Suzuki, F., Ogiwara, T., Satoh, K., Ito, H., Hatano, T., Yoshida T. and Fujisawa, S. (2005) Molecular requirements of lignin–carbohydrate complexes for expression of unique biological activities, Phytochemistry, 66 (17), 2108-2120.
  3. 伊東秀之* (2005) 薬用植物中の酸化型エラジタンニン成分とその生理活性，Natural Medicines, 59 (2), 57-62．

2004

論文

（*Corresponding author）

  1. Ito, H., Gonthier, M.P., Manach, C., Morand, C., Mennen, L., Remesy, C, and Scalbert, A. (2004) High-throughput profiling of dietary polyphenols and their metabolites by HPLC-ESI-MS-MS in human urine, BioFactors, 22, 241-243.
  2. Fukuda, T., Ito, H., Yoshida, T. (2004) Effect of the walnut polyphenol fraction on oxidative stress in type 2 diabetes mice, BioFactors, 21, 251-253.
  3. Shinomiya, K., Omichi, J., Ohnishi, R., Ito, H., Yoshida, T., Kamei, C. (2004) Effects of chlorogenic acid and its metabolites on the sleep-wakefulness cycle in rats, Eur. J. Pharm., 504 (3), 185-189.
  4. Ito, H., Nishida, Y., Yamazaki, M., Nakahara, K., Michalska-Hartwich, M., Furmanawa, M., Leistner, E., Yoshida, T. (2004) Chrysophanol glycosides from callus cultures of monocotyledonous Kniphofia spp. (Asphodelaceae), Chem. Pharm. Bull., 52 (10), 1262-1264.
  5. Ito, H., Iwamori, H., Kasajima, N., Kaneda, M., Yoshida, T. (2004) Kunzeanones A, B, and C: novel alkylated phloroglucinol metabolites from Kunzea ambigua, Tetrahedron, 60 (44), 9971-9976.
    ＊ファルマシア誌，40 (11) 998 (2004) のEditor’s Eyeに紹介されました
  6. Hatano, T., Inada, K., Ogawa, T., Ito, H. and Yoshida, T. (2004) Aliphatic acid amides of the fruits of Zanthoxylum piperitum, Phytochemistry, 65 (18), 2599-2604.
  7. Takagi, Y., Yamana, F., Sumino, Y., Ito, H., Yoshida, T., Kato, T., Miyazawa, K., and Itoh, T. (2004) The synthesis of enantiomerically pure novel liquid crystal compounds containing the bis(trifluoromethyl)alkanediol moiety, Tetrahedron: Asymmetry, 15 (17), 2591-2594.
  8. Ismail, I.S., Ito, H., Hatano, T., Taniguchi, S., Yoshida, T. (2004) Two new analogues of trijugin-type limonoids from the leaves of Sandoricum koetjape, Chem. Pharm. Bull., 52 (9), 1145-1147.
  9. Kim, T.-H., Ito, H., Yoshida, T. (2004) Chemical constituents of Artemisia herba-alba Asso, Natural Medicines, 58 (4), 165.
  10. Hatano, T., Hori, M., Kusuda, M., Ohyabu, T., Ito, H., and Yoshida, T. (2004) Characterization of the oxidation products of (-)-epigallocatechin gallate, a bioactive tea polyphenol, on incubation in neutral solution, Heterocycles, 63 (7), 1547-1554.
  11. Funatogawa, K., Hayashi, S., Shimomura, H., Yoshida, T., Hatano, T., Ito, H., Hirai, Y. (2004) Antibacterial activity of hydrolyzable tannins derived from medicinal plants against Helicobacter pylori, Microbiol. Immunol., 48 (4), 251-261.
  12. Ito, H., Kasajima, N., Tokuda, H., Nishino, H., and Yoshida, T. (2004) Dimeric flavonol glycoside and galloylated C-glucosylchromones from Kunzea ambigua, J. Nat. Prod., 67 (3), 411-415.
  13. Jose H. Isaza, M., Ito, H., and Yoshida, T. (2004) Oligomeric hydrolyzable tannins from Monochaetum multiflorum, Phytochemistry, 65 (3), 359-367.

総説，著書

（*Corresponding author）

  1. 伊東秀之* (2004) 天然色素の分離と構造解析，J. Jpn. Soc. Colour Mater.，77 (3), 138-145.
  2. 吉田隆志，波多野　力，伊東秀之 (2004) 天然ナノ分子タンニン―その構造と機能―，有機合成化学協会誌，62 (5)，500-507.

特許出願

  1. 『酸化ストレス抑制用の食品』
    特願2004-236342
    出願日：平成16年8月16日
    発明者：福田 寿之，吉田 隆志，伊東　秀之
    特許出願人：ポーラ化成工業株式会社
  2. 『新規ジカルボン酸配糖体』
    特願2004-006210
    出願日：平成16年1月14日
    発明者：福田 寿之，吉田 隆志，伊東　秀之
    特許出願人：ポーラ化成工業株式会社

2003

論文

（*Corresponding author）

  1. Kim, T.-H., Ito, H., Yoshida, T. (2003) Constituents of the Quercus suber cork, Natural Medicines, 57 (6), 256.
  2. Ismail, I.S., Ito, H., Hatano, T., Taniguchi, S., Yoshida, T. (2003) Modified limonoids from the leaves of Sandoricum koetjape, Phytochemistry, 64 (8), 1345-1349.
  3. Ismail, I.S., Ito, H., Mukainaka, T., Higashihara, H., Enjo, F., Tokuda, H., Nishino, H., Yoshida, T. (2003) Ichthyotoxic and anticarcinogenic effects of triterpenoids from Sandoricum koetjape bark, Biol. Pharm. Bull., 26 (9), 1351-1353.
  4. Park, J.-C., Ito, H., Yoshida, T. (2003) 1H-NMR assignment of HIV protease inhibitor, procyanidin B-3 isolated from Rosa rugosa, Nat. Prod. Sci., 9 (2), 49-51.
  5. Fukuda, T., Ito, H., Yoshida, T. (2003) Antioxidative polyphenols from walnuts (Juglans regina L.), Phytochemistry, 63 (7), 795-801.
  6. Uchiumi, F., Hatano, T., Ito, H., Yoshida, T., Tanuma, S. (2003) Transcriptional suppression of the HIV promoter by natural compounds, Antiviral Res., 58 (1), 89-98.
  7. Fukuda, T., Ito, H., and Yoshida, T. (2003) Glycosides and their quantitative HPLC analysis of commercial persicae semen, Natural Medicines, 57 (1), 18-22.
  8. Khennouf, S., Benabdallah, H., Gharzouli, K., Amira, S., Ito, H., Kim, T-H., Yoshida, T., and Gharzouli, A. (2003) Effect of tannins from Quercus suber and Quercus coccifera leaves on ethanol-induced gastric lesions in mice, J. Agric. Food Chem., 51, 1469-1473.
  9. Fukuda, T., Ito, H., Mukainaka, T., Tokuda, H., Nishino, H., and Yoshida, T. (2003) Anti-tumor promoting effect of glycosides from Prunus persica seeds, Biol. Pharm. Bull., 26 (2), 271-273.

総説，著書

（*Corresponding author）

  1. 吉田隆志，伊東秀之，波多野　力，坂上　宏，徳田春邦，志村　進 (2003) ビワ葉の抗腫瘍性成分，バイオインダストリー, 20 (2), 27-33.

特許出願

    1. 『糖尿病合併症のための経口投与組成物』
      特願2003-357452
      出願日：平成15年10月17日
      発明者：福田 寿之，吉田 隆志，伊東　秀之
      特許出願人：ポーラ化成工業株式会社
    2. 『糖質消化酵素抑制剤及びそれを含有する組成物』
      特願2003-151851
      出願日：平成15年5月29日
      発明者：福田 寿之，吉田 隆志，伊東　秀之
      特許出願人：ポーラ化成工業株式会社
    3. 『抗真菌剤及びそれを含有する皮膚外用剤』
      特願2003-013311
      出願日：平成15年1月22日
      発明者：吉田 隆志，伊東　秀之，岡本 敬の介，北田 好男，片桐 崇行
      特許出願人：ポーラ化成工業株式会社，吉田 隆志，伊東　秀之，岡本 敬の介
    4. 『クルミの仁由来のポリフェノール』
      特願2003-005774
      出願日：平成15年1月14日
      発明者：福田 寿之，吉田 隆志，伊東　秀之
      特許出願人：ポーラ化成工業株式会社

2002

論文

（*Corresponding author）

  1. Ito, H., Koreishi, M., Jin, Z.-X., and Yoshida, T. (2002) Phenolic compounds from Dryopteris fragrans, Natural Medicines, 56 (6), 273.
  2. Taniguchi, S., Uechi, K., Ito, H., Hatano, T,. Yazaki, K., and Yoshida, T. (2002) Accumulation of hydrolyzable tannins by Aleurites fordii callus culture, Planta Medica, 68, 1145-1146.
  3. Taniguchi, S., Imayoshi, Y., Kobayashi, E., Takamatsu, Y., Ito, H., Hatano, T,. Sakagami, H, Tokuda, H., Nishino, H., Sugita, D., Shimura, S., Yoshida, T. (2002) Production of bioactive triterpenes by Eriobotrya japonica calli, Phytochemistry, 59, 315-323.
  4. Taniguchi, S., Imayoshi, Y., Yabu-uchi, R., Ito, H., Hatano, T,. Yoshida, T. (2002) A macrocyclic ellagitannin trimer, oenothein T1, from Oenothera species, Phytochemistry, 59, 191-195.
  5. Hatano, T., Miyatake, H., Natsuma , M, Osakabe, N., Takizawa, T., Ito, H., Yoshida, T. (2002) Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects, Phytochemistry, 59 (7), 749-758.
  6. Ito, H., Yamaguchi, K., Kim, T.-H., Khennouf, S., Gharzouli, K. and Yoshida, T. (2002) Dimer and trimeric hydrolyzable tannins from Quercus coccifera and Quercus suber, J. Nat. Prod., 65 (3), 339-345.
  7. Ito, H., Kobayashi, E., Li, S-H., Hatano, T., Sugita, D., Kubo, N., Shimura, S., Itoh, Y., Tokuda, H., Nishino, H., and Yoshida, T., (2002) Antitumor activity of compounds isolated from leaves of Eriobotrya japonica, J. Agric. Food Chem., 50 (8), 2400-2403.
  8. Amakura, Y., Umino, Y., Tsuji, S., Ito, H., Hatano, T., Yoshida, T., Tonogai, Y., (2002) Constituents and their antioxidative effects in Eucalyptus leaf extract used as a natural food additive, Food Chemistry, 77 (1), 47-56.

特許出願

  1. 『抗酸化組成物』
    特願2002-103523
    出願日：平成１４年４月５日
    発明者：福田 寿之，吉田 隆志，伊東　秀之
    特許出願人：ポーラ化成工業株式会社

2001

論文

（*Corresponding author）

  1. Ito, H., Kobayashi, E., Li, S-H., Hatano, T., Sugita, D., Kubo, N., Shimura, S., Itoh, Y. and Yoshida, T. (2001) Megastigmane glycosides and an acylated triterpenoid from Eriobotrya japonica, J. Nat. Prod., 64 (6), 737-740.
  2. Kolodziej, H., Kayser, O., Kiderlen, A., Ito, H., Hatano, T., Yoshida, T. and Foo, L. Y. (2001) Proanthocyanidins and related compounds: Antileishmanial activity and modulatory effects on nitric oxide and tumor necrosis factor-α-release in the murine macrophage-like cell line RAW 264.7, Biol. Pharm. Bull., 24 (9), 1016-1021.
  3. Ito, H., Onoue, S. and Yoshida, T. (2001) Isoflavonoids from Belamcanda chinensis, Chem. Pharm. Bull., 49 (9), 1229-1231.
  4. Ito, H., Nishitani, E., Hatano , T., Nakanishi, T., Inada, A., Murata, H., Inatomi , Y., Matsuura, N., Ono, K., Lang, F. A., Murata, J., and Yoshida, T. (2001) Tannins and related polyphenols, HIV reverse transcriptase inhibitors, from Rosa woodsii, Natural Medicines, 55 (4), 218.
  5. Jose H. Isaza, M., Ito, H., and Yoshida, T. (2001) A novel flavonol glycoside-lignan ester and accompanying acylated glucosides from Monochaetum multiflorum, Phytochemistry, 58 (2), 321-327.
  6. Shimizu, M., Shiota, S., Mizushima , T., Ito, H., Hatano, T., Yoshida, T., and Tsuchiya, T. (2001) Marked potentation of activity of β-lactam against methicillin-resistant Staphylococcus aureus by corilagin, Antimicrob. Agents Chemother., 45 (11), 3198-3201.
  7. Ito, H., Li, P., and Yoshida, T. (2001) Hydrolyzable tannins from Ostryopsis davidiana, Natural Medicines, 55 (6), 314.
  8. Kolodziej, H., Kayser , O., Kiderlen, A., Ito, H., Hatano, T., Yoshida, T. and Foo, L. Y. (2001) Antileishmanial activity of hydrolyzable tannins and their modulatory effects on nitric oxide and tumor necrosis factor a release in macrophages in vitro, Planta Medica, 67, 825-832.
  9. Jose H. Isaza, M., Ito, H., and Yoshida, T. (2001). Tetrameric and pentameric ellagitannins from Monochaetum multiflorum, Heterocycles, 55 (1), 29-32.

寄稿，Proceedings，報告書等書

  1. 伊東秀之 (2001) 第20回国際ポリフェノール会議参加報告，日本農芸化学会誌，75 (1), 46-48.
  2. Ito, H., Jose H. Isaza, M., and Yoshida, T. (2001) Ellagitannin oligomers from melastomataceous plants, 43rd Symposium on The Chemistry of Natural Products, Symposium papers pp. 175-180.

特許出願

  1. 『発ガンプロモーター抑制剤及びそれを含有する組成物』
    特願2001-310890
    出願日：平成１３年１０月９日
    発明者：福田 寿之，吉田 隆志，伊東　秀之，西野 輔翼
    特許出願人：ポーラ化成工業株式会社

2000

論文

（*Corresponding author）

  1. Hatano, T., Aga, Y., Shintani, Y., Ito, H., Okuda, T., Yoshida, T. (2000) Minor flavonoids from licorice, Phytochemistry, 55 (8), 959-963.
  2. Ito, H., Koreishi, M., Tokuda, H., Nishino, H., and Yoshida, T. (2000) Cypellocarpins A-C, phenol glycosides esterified with oleuropeic acid, from Eucalyptus cypellocarpa, J. Nat. Prod., 63 (9), 1253-1257.
  3. Ito, H., Saeed, A., and Yoshida, T. (2000) Polyphenolic constituents of Callistemon speciosus, Natural Medicines, 54 (4), 204.
  4. Ito, H., Nishitani, E., Konoshima, T., Takasaki, M., Kozuka, M., and Yoshida, T. (2000) Flavonoid and benzophenone glycosides from Coleogyne ramosissima., Phytochemistry, 54 (7), 695-700.
  5. Ito, H., Muranaka, T., Mori, K., Jin, Z-X., Tokuda, H., Nishino, H., and Yoshida, T. (2000) Ichthyotoxic phloroglucinol derivatives from Dryopteris fragrans and their anti-tumor promoting activity, Chem. Pharm. Bull., 48 (8), 1190-1195.
  6. Kanoh, R., Hatano, T., Ito, H., Yoshida, T., and Akagi, M. (2000) Effect of tannins and related polyphenols on superoxide-induced histamine release from rat peritoneal mast cells, Phytomedicine, 7 (4), 297-302.
  7. Shiota, S., Shimizu, M., Mizushima, T., Ito, H., Hatano, T., Yoshida, T., and Tsuchiya, T. (2000) Restoration of effectiveness of -lactams in methicillin-resistant Staphylococcus aureus by tellimagrandin I from rose red., FEMS Microbiol. Lett., 185, 135-138.
  8. Ito, H., Kobayashi, E., Takamatsu, Y., Li, S-H., Hatano, T., Sakagami, H., Kusama, K., Satoh, K., Sugita, D., Shimura, S., Itoh, Y., and Yoshida, T. (2000) Polyphenols from Eriobotrya japonica and their cytotoxicity against human oral tumor cell lines, Chem. Pharm. Bull., 48 (5), 687-693.
  9. Sakagami, H., Jiang, Y., Kusama, K., Atsumi, T., Ueha, T., Toguchi, M., Iwakura, I., Satoh, K., Ito, H., Hatano, T., and Yoshida, T. (2000) Cytotoxic activity of hydrolyzable tannins against human oral tumor cell lines – A possible mechanism, Phytomedicine, 7 (1), 39-47.
  10. Taniguchi, S., Yazaki, K., Yabu-uchi, R., Kawakami, K., Ito, H., Hatano, T., and Yoshida, T. (2000) Galloylglucoses and riccioidin A in Rhus javanica adventitious root cultures, Phytochemistry, 53 (3), 357-363.

総説，著書

（*Corresponding author）

  1. Yoshida T. and Ito H. (2000) Naturally occurring ichthyotoxic substances and their biological activities, Current Topics in Phytochemistry, 4, 135-145.
  2. Yoshida, T., Hatano, T., Ito, H. (2000) Chemistry and function of vegetable polyphenols with high molecular weights, BioFactors, 13, 121-125.
  3. Yoshida, T., Hatano T., Ito, H., Okuda, T. (2000) Chemical and biological perspective of ellagitannin oligomers from medicinal plants., A.U. Rahman (Ed.), Studies in Natural Products Chemistry, Vol. 23: Bioactive Natural Products (Part D), Elsevier Science, Amsterdam, 395-453.

1999

論文

（*Corresponding author）

  1. Shiota, S., Shimizu, M., Mizushima, T., Ito, H., Hatano, T., Yoshida, T., and Tsuchiya, T. (1999) Marked reduction in the minimum inhibitory concentration (MIC) of -lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis), Biol. Pharm. Bull., 22 (12), 1388-1390.
  2. Jose H. Isaza, M., Ito, H., and Yoshida, T. (1999) Monochaetin, A di-hyperin ester of tetrahydroxy--truxinic acid from Monochaetum multiflorum, Chem. Pharm. Bull., 47 (10), 1510-1511.
  3. Yoshida, T., Amakura, Y., Yokura, N., Ito, H., Isaza, J.H., Remirez, S., Pelaez, D.P., and Renner, S.S. (1999) Oligomeric hydrolysable tannins from Tibouchina multiflora., Phytochemistry, 52 (8), 1661-1666.
  4. Hatano, T., Mizuta, S., Ito, H., and Yoshida, T. (1999) C-Glycosidic flavonoids from Cassia occidentalis., Phytochemistry, 52 (7), 1379-1383.
  5. Hatano, T., Uebayashi, H., Ito, H., Shiota, S., Tsuchiya, T., and Yoshida, T. (1999) Phenolic constituents of cassia seeds and antibacterial effects of some naphthalenes and anthraquinones on methicillin-resistant Staphylococcus aureus., Chem. Pharm. Bull., 47 (8), 1121-1127.
  6. Ito, H., Hatano, T., Namba, O., Shirono, T., Okuda, T., and Yoshida, T. (1999) Constituents of Geranium thunbergii Sieb. et Zucc. XV. Modified dehydroellagitannins, geraniinic acids B and C, and phyllanthusiin F, Chem. Pharm. Bull., 47 (8), 1148-1151.
  7. Ito, H., Miyake, M., Nishitani, E., Mori, K., Hatano, T., Okuda, T., Konoshima, T., Takasaki, M., Kozuka, M., Mukainaka, T., Tokuda, H., Nishino, H., and Yoshida, T. (1999) Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima, Cancer Letters, 143, 5-13.
  8. Ito, H., Miki, K., and Yoshida, T. (1999) Elaeagnatins A-G, C-glucosidic ellagitannins from Elaeagnus umbellata., Chem. Pharm. Bull., 47 (4), 536-542.
  9. Ito, H., Onoue, S., Miyake, Y., and Yoshida, T. (1999) Iridal-type triterpenoids with ichthyotoxic activity from Belamcanda chinensis, J. Nat. Prod., 62 (1), 89-93.
  10. Amakura, Y., Miyake, M., Ito, H., Murakaku, S., Araki, S., Itoh, Y., Lu, C-F., Yang, L-L., Yen, K-Y., Okuda, T., and Yoshida, T. (1999) Acalyphidins M1, M2, and D1, ellagitannins from Acalypha hispida, Phytochemistry, 50 (4), 667-675.

寄稿，Proceedings，報告書等書

  1. 吉田隆志，波多野力，伊東秀之，半田山および周辺に生育する薬用植物のポリフェノール成分の研究　—ビワ葉のポリフェノールおよびそれらの抗腫瘍効果—，都市近郊林（半田山）の自然特性およびその環境保全機能に関する研究（XIV），平成１１年度岡山大学教育研究学内特別経費研究成果報告書．

総説，著書

（*Corresponding author）

  1. Yoshida, T., Hatano T., Ito, H., and Okuda, T. (1999) Highly oxidized ellagitannins and their biological activity, In: Gross, G.G., Hemingway, R.W., Yoshida, T. (Eds.), Plant Polyphenol 2. Chemistry, Biology, Pharmacology and Ecology, Kluwer Academic/Pleum Publishers, New York, 127-144.
  2. Yoshida, T., Hatano, T., and Ito, H. (1998) Geraniin-related ellagitannins of the Euphorbiaceae., In: Ageta, H., Aimi, N., Ebizuka, Y., Fujita, T and Honda, G. (Eds.), Towards Natural Medicine Research in the 21st Century (Elsevier Science B. V.), 549-560.

特許出願

  1. 『抗菌作用の増強方法』
    特願平11-250967
    出願日：平成１１年９月３日
    発明者：清水 正登，塩田 澄子，安田 慶子，上林 裕始，波多野 力，伊東　秀之，土屋 友房，吉田 隆志
    特許出願人：株式会社林原生物化学研究所
  2. 『抗発癌プロモーター剤』
    特願平11-037703
    出願日：平成１１年２月１６日
    発明者：吉田 隆志，波多野 力，伊東　秀之，久保 直樹，杉田 大悟，志村 進，伊東 禧男
    特許出願人：株式会社ロッテ
  3. 『皮膚外用剤として有用なベンゾ［Ｂ］ピラン誘導体』
    特願2000-529326
    出願日：平成１１年１月２８日
    発明者：服部 孝雄，片桐 崇行，北田 好男，吉田 隆志，伊東　秀之
    特許出願人：ポーラ化成工業株式会社

1998

論文

（*Corresponding author）

  1. Suganuma, M., Okabe, S., Oniyama, M., Tada, Y., Ito, H., and Fujiki, H. (1998) Wide distribution of 3H-(-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue, Carcinogenesis, 19 (10), 1771-1776.
  2. Taniguchi, S., Nakamura, N., Nose, M., Takeda, S., Yabu-uchi, R., Ito, H., Yoshida, T., and Yazaki, K. (1998) Production of macrocyclic ellagitannin oligomers by Oenothera laciniata callus culture., Phytochemistry, 48, 981-985.
  3. Jin, Z-X., Ito, H., and Yoshida, T. (1998) Ellagitannin dimer and trimer from Corylus heterophylla, Phytochemistry, 48 (2), 333-338.
  4. Hatano, T., Takagi, M., Ito, H., and Yoshida, T. (1998) Acylated flavonoid glycosides and accompanying phenolics from licorice, Phytochemistry, 47, 287-293.

1997

論文

（*Corresponding author）

  1. Matsuo, K., Kobayashi, M., Takuno, Y., Kuwajima, H., Ito, H., and Yoshida, T. (1997) Anti-tyrosinase activity constituents of Arctostaphylos uva-ursi, Yakugaku Zasshi, 117, 1028-1032.
  2. Ito, H., Muranaka, T., Mori, K., Jin, X.-M., and Yoshida, T. (1997) Dryofragin and aspidin PB, piscicidal components from Dryopteris fragrans, Chem. Pharm. Bull., 45 (10), 1720-1722.
  3. Hatano, T., Takagi, M., Ito, H., and Yoshida, T. (1997) Phenolic constituents of liquorice. VII. A new chalcone with a potent radical scavenging activity and accompanying phenolics from licorice, Chem. Pharm. Bull., 45 (9), 1485-1492.
  4. Hatano, T., Yamashita, A., Hashimoto, T., Ito, H., Kubo, N., Yoshiyama, M., Shimura, S., Itoh, Y., Okuda, T., and Yoshida, T. (1997) Flavan dimers with lipase inhibitory activity from Cassia nomame, Phytochemistry, 46, 893-900.
  5. Miyake, Y., Ito, H., and Yoshida, T. (1997) Identification of iridals as piscicidal components of iridaceous plants and their conformations associated with CD Spectra, Can. J. Chem., 75, 734-741.

1996

論文

（*Corresponding author）

  1. Haque, M., Hirai, Y., Yokota, K., Mori, N., Jahan, I., Ito, H., Hotta, H., Yano, I., Kanemasa, Y., and Oguma, K. (1996) Lipid profile of Helicobacter spp.: Presence of cholesteryl glucoside as a characteristic feature, J. Bacteriol., 178 (7) 2065-2070.
  2. Itoh, T., Chika, J., Shirakami, S., Ito, H., Yoshida, T., Kubo, Y., and Uenishi, J. (1996) Synthesis of trideca-O-methyl--pedunculagin. Diastereofavoritism studies on intramolecular estercyclization of axially chiral biphenic acids with carbohydrate core, J. Org. Chem., 61, 3700-3705.
  3. Yoshida, T., Ito, H., Hatano, T., Kurata, M., Nakanishi, T., Inada, A., Murata, H., Inatomi, Y., Matsuura, N., Ono, K., Nakane, H., Noda, M., Lang, F. A., and Murata, J. (1996) New hydrolyzable tannins as HIV reverse transcriptase inhibitors from Shepherdia argentea, Chem. Pharm. Bull., 44 (8), 1436-1439.

1995

論文

（*Corresponding author）

  1. Kanoh, R., Fukuishi, N., Katakuse, Y., Yoshida, T., Hatano, T., Ito, H., and Akagi M. (1995) Inhibitory effects of tannins on superoxide-induced histamine release from rat peritoneal mast cells, Folia Pharmacol. Jpn., 106, 207-211.
  2. Ito, H., Miyake, Y., and Yoshida, T. (1995) New piscicidal triterpenes from Iris germanica, Chem. Pharm. Bull., 43 (7), 1260-1262.

寄稿，Proceedings，報告書等書

  1. Ito, H., Hatano, T., Miyake, M., Yoshida, T., Kozuka, M., Tokuda, H., and Okuda, T. (1995) Tannins from Cowania mexicana, and their inhibitory effects on TPA-induced EBV activation, In: Brouillard, R., Jay, M. and Scalbert, A. (Eds.), Polyphenols 94, Institut National de la Recherche Agronomique (INRA), Paris, 419-420.

1992

論文

（*Corresponding author）

  1. Yoshida, T., Ito, H., Matsunaga, S., Tanaka, R., Okuda, T. (1992) Tannins and related polyphenols of euphorbiaceous plants. IX. Hydrolyzable tannins with 1C4 glucose core from Phyllanthus flexuosus MUELL. ARG., Chem. Pharm. Bull., 40 (1), 53-60.